10 S e c r e t a r i a t m e a ns t he e nt i t y r e spons i bl e f or a ss i st i ng i n t he da i l y m a na g e m e nt of t he C onsor t i um a s de sc r i be d i n C ha pt e r V I 4 S I E F st a nds f or S ubst a nc e I nf o r m a t i on E x c ha nge F or um S t udi e s m e a ns t e st s or e va l ua t i ons i nc l udi ng sum m a r i e s a nd r obust st ud y sum m a r i e s r e l a t i ng t o i nt r i nsi c pr op e r t i e s e x posur e a ss e ss m e nt a nd r i sk c ha r a c t e r i sa t i on of subs t a nc e s S t ud y sum m a r y m e a ns a sum m a r y of t h e obj e c t i ve s m e t hods r e sul t s a n d c onc l usi ons of a f ul l st ud y r e po r t pr ovi di ng suf f i c i e nt i nf or m a t i on t o m a ke a n a ss e ss m e nt of t he r e l e v a nc e o f t he st ud y S ubst a nc e s m e a ns t he subs t a nc e s i nt e nde d f o r R e g i st r a t i on unde r t hi s a g r e e m e nt a s l i st e d i n C ha pt e r I V B T hi r d P a r t y m e a ns a n y pa r t y not si g na t or y t o t hi s A g r e e m e nt T r ust e e m e a ns a l e g a l or na t ur a l pe r son a ppoi nt e d b y t he A ss e m bl y t hr ou g h a c onf i de nt i a l i t y A gr e e m e nt t o r e c e i ve r e c or d a nd a ggr e g a t e a n y c onf i d e nt i a l da t a t ha t w oul d be di sc l ose d b y a m e m b e r of t he C onsor t i um or a t hi r d pa r t y T he T r ust e e m ust e nsur e t ha t spe c i f i c i nt e r n a l pr oc e dur e s pr ot e c t e f f e c t i ve l y c on f i de nt i a l da t a di sc l ose d t o hi m IV P U R P O S E A N D S C O P E O F T H E C O N S O R T IU M IN C L U D IN G S U B S T A N C E D E F IN IT IO N 1 P urpos e Mor e spe c i f i c a l l y t h e Me m be r s a i m t o a c hi e v e uni f or m p r e R e g i st r a t i on of t he R e l e va nt S ubst a nc e s a nd pr e pa r a t i on a nd subm i ss i on of C o r e D a t a f or t he R e g i st r a t i on of t he R e l e va nt S ubst a nc e s a nd t o t ha t e f f e c t t he y unde r t a k e t o r e vi e w a nd sha r e e x i st i ng da t a f i l l da t a g a ps a nd sha r e t he c ost s i nc ur r e d i n de v e l opi ng m i ss i ng d a t a i n a c c o r da n c e w i t h t he pr ovi si on of t hi s A g r e e m e nt A c c or di n g l y t he Me m be r s of t he C onsor t i um ha ve de c i d e d t o j oi n f o r c e s i n or de r t o pur sue t he f ol l ow i ng a ddi t i ona l pur pose s C om pi l e a nd a ss e ss e x i st i ng st udi e s not i nvol vi ng ve r t e br a t e a ni m a l s P r e pa r e p r oposa l f or n e w t e st i ng not i nvol vi ng ve r t e br a t e a ni m a l s a n d pe r f o r m t he m I d e nt i f y pr opose a nd p e r f or m j oi nt l y ve r t e br a t e a ni m a l S t udi e s w he r e ne c e ss a r y f or r e g i st r a t i on i n or de r t o l i m i t t he nu m be r of suc h S t udi e s c onduc t e d a s r e qui r e d a c c or di n g t o t he R E A C H r e g ul a t i on